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The FBI's International Response Team go to Thailand where three American volunteers go missing during a trek to Bangkok.
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When an American man wakes up missing a kidney and his friend gone while attending a festival in Mumbai, the investigation leads to the possibility that the UnSub is more than just trading organs on the Black Market.
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In Cairo, an Egyptian-American former U.S. serviceman is killed in a gas attack and his friend goes missing.
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The team heads to Japan where they assist local law enforcement to investigate a series of homicides made to look like suicides.
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The International Response Team looks for an UnSub targeting Americans who live in Paris.
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The team goes to Belize to find a missing couple who vanishes on their honeymoon in what seems to be a planned abduction.
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The International Response Team travels to Morocco when a retired couple from Idaho is kidnapped while visiting the country on a cruise.
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When a woman vacationing in Mexico with her family is the victim of foul play, the International Response Team investigates her husband as the prime suspect when he flees.
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When an American girl leaves home to meet her boyfriend in Turkey, the International Response Team suspects she’s in trouble after being tricked by someone posing as her boyfriend.
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When an American college student working in Johannesburg is killed and his brother goes missing, the International Response Team suspects a gang could be behind both. Jack works the case with Lieutenant Ananda Doshi, a profiler he’s worked with before who has an unorthodox style of investigation.
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When American victims are found in different locations throughout Cuba, the International Response Team heads to the island nation to search for possible spree killers.
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The IRT heads to Pamplona, Spain, for the running of the bulls, where the ears of a missing American tourist are found.
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When the daughter of an American family visiting Haiti to adopt a child is kidnapped, the International Response Team travels to the island nation to try to find her. Also, Jack and his wife, Karen, prepare to send their daughter to college.